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butabarbital will minimize the extent or effect of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Impact of coadministering a solid CYP3A4 inducer with fedratinib hasn't been examined.butabarbital will lessen the level or result of glecaprevir/pibrentasvir by influencing hepatic/intestinal